infectious disease
tsmith | June 5, 2011The E. coli story is moving quickly. A news report out today suggests that sprouts might be the culprit (though it should be emphasized that the outbreak strain hasn't been isolated from these vegetables yet):
Mr Lindemann said epidemiological studies all seemed to point to the plant nursery in Uelzen in the state of Lower Saxony, about 100km (62m) south of Hamburg - though official tests had not yet shown the presence of the bacteria there.
"Further evidence has emerged which points to a plant nursery in Uelzen as the source of the EHEC cases, or at least one of the sources," he said.
"The…
tsmith | June 3, 2011Mike has has a great new post up looking at some molecular analyses of the current European outbreak strain. For anyone who hasn't been paying close attention to what's happening across the pond, there's an ongoing outbreak of enterohemorrhagic E. coli (EHEC)--the type of E. coli that includes O157:H7, which has been associated with outbreaks of disease associated with food. The most infamous outbreak was the 1993 Jack-in-the-Box disaster, associated with undercooked hamburgers contaminated with the organism, but there have also been outbreaks associated with contaminated vegetables (such as…
tsmith | June 3, 2011...when it contains a weird gene conferring methicillin resistance that many tests miss.
Methicillin-resistant Staphylococcus aureus (MRSA) has become a big issue in the past 15 years or so, as it turned up outside of its old haunts (typically hospitals and other medical facilities) and started causing infections--sometimes very serious--in people who haven't been in a hospital before. Typically MRSA is diagnosed using basic old-school microbiology techniques: growing the bacteria on an agar plate, and then testing to see what antibiotics it's resistant to. This can be done in a number of…
tsmith | June 2, 2011At the new blog Puff the Mutant Dragon, there's a great pair of posts looking at the history of plague, with a focus on outbreaks that have occurred here in the US.
Bubonic Plague in America, Part I: LA Outbreak
Bubonic Plague in America, Part II: Undercover Science
I'll also link them in my Black Plague series.
tsmith | May 30, 2011In the United States, we tend to take our clean drinking water for granted. Even though there are periodic concerns which bubble up about pharmaceuticals or other chemicals in our water supply, we typically believe--with good reason--that we have little to fear when it comes to contamination from microbes. Our drinking water, while far from perfect, is heads and shoulders above what it once was--something many of us forget or have never realized. There have been notable breakdowns, such as the 1993 outbreak of Cryptosporidium in Milwaukee that sickened over 400,000 individuals, but these days…
tsmith | May 24, 2011We've had pertussis and mumps, so it was only a matter of time.
State health officials declared a "public health emergency" Tuesday after a test confirmed a case of measles in an unvaccinated Dallas County baby who apparently picked up the disease in India.
They said people who might have been exposed included passengers on an Americans Airline flight from Chicago to Des Moines May 11 and people who were at Mercy Medical Center or a Mercy pediatric clinic in downtown Des Moines May 14.
Dr. Patricia Quinlisk, medical director for the Iowa Department of Public Health, said many Americans…
tsmith | May 18, 2011Ebola has long been associated with wildlife. From the early days, bats were viewed as a potential reservoir (though it wasn't confirmed that they actually harbored the virus until 2005). Contact with wild animals--particularly primates which were butchered for food--was also long thought to be a risk factor, and now we know that primates can become ill with Ebola and pass the virus to humans.
What hadn't been examined until 2008 were pigs. I mean, it's not exactly the animal you associate with central Africa, where many of the Ebola cases have been concentrated. However, pigs are much more…
tsmith | May 16, 2011Via H5N1 and other sources, there's at least one new Ebola case in Uganda:
The rare and deadly Ebola virus has killed a 12-year-old Ugandan girl and health officials said on Saturday they expected more cases.
The girl from Luwero district, 75 km (45 miles) north of the capital Kampala, died on May 6, said Anthony Mbonye, the government's commissioner for community health, in the first outbreak of the virus in Uganda in four years.
"Laboratory investigations have confirmed Ebola to be the primary cause of the illness and death. So there is one case reported but we expect other…
tsmith | May 13, 2011It's been not even a month since the last paper looking at MRSA in meat, and up pops another one. So far here in the US, we've seen studies in Rhode Island (no MRSA found); Louisiana (MRSA found in beef and pork, but "human" types: USA100 and USA300); the recent Waters et al study sampling in California, Florida, Illinois, Washington DC, and Arizona, finding similar strains (ST8 and ST5, associated with USA300 and USA100, respectively). Now a new study has collected MRSA samples in Detroit, collecting 289 samples from 30 retail stores in the city.
For this study, they collected only beef,…
tsmith | May 12, 2011An ahead-of-print paper in Emerging Infectious Diseases is generating some buzz in the mainstream media. While the findings are interesting, I'm honestly not sure how they got published, being so preliminary.
Like many areas, Vancouver, British Columbia has seen a jump in the prevalence of bedbugs. After finding impoverished patients infested with the bugs, researchers decided to collect some and test them for pathogens--specifically, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). So, they tested 5 bugs from 3 patients. That's it--it doesn't…
tsmith | May 10, 2011Maryn McKenna was awesome enough to take some time out of her vacation to blog about our recent ST398 paper, finding "livestock-associated" S. aureus in a daycare worker. She raised one question I didn't really address previously, regarding our participation by kids and workers at the facility (eight kids out of 168, and 24 out of 60 staff members).
(Staph screening is very non-invasive, by the way; it effectively involves twirling a long-handled Q-tip inside the front of your nostrils. Kinda makes you wonder why families would not have wanted to participate. On the other hand, since Iowa is…
tsmith | April 29, 2011Maryn McKenna has an excellent post on 2008's measles outbreak in Arizona. 14 confirmed patients, 8,321 individuals tracked down, 15,120 work hours lost at 7 Arizona hospitals due to furloughs of staff who were not appropriately vaccinated, and almost $800,000 spent by 2 hospitals just to contain the disease--and it all could have been prevented.
tsmith | April 25, 2011Just received an email from Vector-Borne and Zoonotic Diseases saying that my recent article, The Emergence of Staphylococcus aureus ST398, will be available for free online for the next two weeks. It was submitted roughly a year ago so it's already a bit dated in this quick-moving field, but provides an overview of "livestock-associated" MRSA up to mid-2010 or so--including food-associated MRSA.
tsmith | April 25, 2011The Times Square Jumbotron ad keeps trucking, and with it frustration from the medical and public health community. The American Academy of Pediatrics sent a letter to CBS Outdoors, asking them to pull the ad, to no avail. Rahul Parikh thinks it's time to do more:
We in medicine need more than letters and passive education for parents on a website. What we really need are some Mad Men of our own. If you want guidance, look at what the folks at the the American Legacy Foundation have done with their anti-smoking campaign, The Truth. Who can forget the TV commercial where a truck pulls up to…
tsmith | April 19, 2011As Maryn McKenna and others have reported, a paper was released on Friday showing a high percentage of drug-resistant Staphylococcus aureus contaminating raw, retail-available meat products. There has been a lot of media coverage of this finding--so what does the study say, and what are its implications? More after the jump.
First, a bit about S. aureus itself, and why this study was carried out. Historically, Staph has been a relatively common cause of food poisoning. The bacterium produces toxins that can collect to a high level when prepared foods are left at room temperature, such as…
tsmith | April 11, 2011We all know of once-respected scientists who ended up going off the deep end, adhering to an unproven idea despite massive evidence to the contrary. Linus Pauling and his advocacy of megadoses of Vitamin C, or Peter Duesberg's descent into HIV denial. It's all the more disappointing when the one taking a dive is a woman, since there are, compared to men, relatively fewer female "big names" in the sciences. So when one goes from views that were, perhaps, outside of the mainstream (but later proven largely correct) to complete science denialism, it makes it all the more depressing. Even worse,…
tsmith | April 8, 2011Via Skepchick, CBS will be airing ads from the National Vaccine Information Center and Mercola on the CBS Jumbotron in Time's Square (NVIC announcement here). This, while there's a measles outbreak in Minnesota (and another one being investigated in Utah), and we're on the heels of the worst pertussis outbreak in generations in California. Shameful.
Hello,
I recently learned that CBS will be playing ads featuring misinformation by the National Center for Vaccine information Vaccine Information Center. These ads are misleading and potentially dangerous. Vaccine-preventable illnesses have had…
tsmith | April 4, 2011Next to Ebola, my favorite virus would probably be smallpox (Variola virus). I mean, now that it's eradicated in nature, what's not to love about the mysteries it's left us--where it came from, why it was so deadly (or, not so deadly, as in the emergence of the "mild" form, variola minor), and will a new poxvirus emerge to take its place? The topic is particularly germane since the debate still rages on about the fate of the world's smallpox stocks. Smallpox has killed untold millions and influenced the destiny of societies; and as Michael Willrich details in his new book, Pox: An American…
tsmith | March 29, 2011One of the reasons I've not been blogging as much over the past 2 years or so is that it's been just insane in the lab. As I was still living off start-up funds and pilot grants, I didn't have anyone full-time to take care of everything, so all the work has been done by myself and a handful of excellent graduate & undergrad students. Happily, some of the initial projects are wrapping up, and publications are starting to come out (I'll be blogging about others in the coming days/weeks). One of them was published yesterday in Emerging Infectious Diseases: Livestock-associated…
tsmith | March 28, 2011There has been a surge of interest recently in science denial, particularly revolving around the issue of vaccines. Last year saw the release of Michael Specter's Denialism; in the last few months, three others have been released: Seth Mnookin's Panic Virus, Robert Goldberg's Tabloid Medicine, and Paul Offit's "Deadly Choices." More about each of them after the jump.
"The Panic Virus" by Seth Mnookin focuses on the general topic of media-fueled science denial, using vaccines as the case study. Like Offit's recent "Autism's False Prophets, Mnookin details a bit of the history of the anti-…