drugs of abuse
terrasig | July 1, 2009Judging from the press inquiries I've had since 5 am EDT today, expect today's focus in the Michael Jackson case to be on the anesthetic drug, propofol (Diprivan®).
Last evening, California nutritionist and registered nurse Ms Cherilyn Lee gave an interview to Campbell Brown on CNN (and this AP exclusive report) describing Michael Jackson's repeated requests of her for the intravenous sedative drug for his insomnia. She wisely rejected his requests, instead providing him with a vitamin and mineral "energy" injection called Myers' cocktail.
However, four days before Jackson's death she…
terrasig | June 26, 2009AOL's celebrity gossip page TMZ.com was first yesterday to report Michael Jackson's death, in part due to their direct line to one or more Jackson family members.
They appear to have had another scoop today in referencing a family member who reported that Mr Jackson had received an injection of the opioid analgesic, Demerol (meperidine), at 11:30 am yesterday. It is not clear whether this shot was administered by Dr Conrad Murray, the physician who was present when the 911 call was made to L.A. dispatchers. (Non-US readers may also refer to meperidine as pethidine or the trade name, Pethadol…
terrasig | June 26, 2009
Figure 1. SouthernFriedScientist (@SFriedScientist) and Kevin Zelnio (Deep Sea News; @kzelnio) and their 40s preparing to leave to attend the 4th International Symposium on Chemosynthesis-Based Ecosystems - Hydrothermal Vents, Seeps and Other Reducing Habitats - in Okinawa, Japan. Yes, Dr Zelnio, those are absolutely gorgeous beards.
I don't know if Kim Severson of the New York Times knew this when writing her thought-provoking article earlier this week, but it coincided with the annual meetings of the Research Society on Alcoholism (RSA) and the College of Problems on Drug Dependence (…
terrasig | June 14, 2009Salvia divinorum (Salvia, Magic Mint) is a plant used for entheogenic purposes by the Mazatec people of Mexico. A relative of the common garden plant "scarlet sage" (Salvia splendens), S. divinorum contains several hallucinogens that include salvinorin A, the first non-nitrogenous agonist known for kappa opioid receptors (KOR).
I had known of salvinorin A since a highly-cited 2002 Proceedings of the National Academy of Sciences paper by Bryan Roth, Richard Rothman and colleagues (full text here). At that time, I had read several anecdotal reports (that I cannot locate now) that the…
terrasig | May 31, 2009When one thinks of a heroin user, thoughts most often come to mind of a person living in squalor in a big metropolitan city or that of an artsy, poetic hipster (while there are many literary works on the life of heroin users, my all-time favorite is Basketball Diaries, an autobiographical account written by Jim Carroll during the ages of 12 to 15. From this description of Carroll's two works on his life with heroin at the catholicboy.com website of Carroll scholar, Dr Cassie Carter: "After reading about 30 pages of the Diaries, [Jack] Kerouac stated that 'at the age of 13, Jim Carroll writes…
terrasig | May 28, 2009A recent discussion with some of my neuropharmacology colleagues led me to go back through the cobwebs and revisit the Terra Sig archives for posts on drugs of abuse. The following was my third post ever and the first on actual scientific substance (the first two were introductions: a hello post and an explanation of what the heck Terra Sigillata actually is).
The following post appeared at the Blogspot home of Terra Sigillata on 26 December 2005.
Let me start by saying that the draconian US laws in the 'war against drugs' would ever prevent the following from happening here:
Sounds like a…
terrasig | April 20, 2009While I was all caught up today with thinking about the 95th anniversary of the Ludlow Massacre and the 10th anniversary of the Columbine High School shootings, I was reminded of some lighthearted goings-on in Colorado today that take away some of the gloom on this Monday. (The Ludlow post is getting great traffic, by the way, but my historical posts on tragedies fail to generate much commenting for some odd reason.).
My good friends at Denver's Westword independent weekly paper tweeted me last week with this headline on from their blog, The Latest Word:
CU Chancellor, obviously high, sends…
terrasig | March 31, 2009A little over a week ago, we posted on the very sad story of the accidental death of a University of Colorado sophomore from ingesting poppy seed tea. The poppy, Papaver somniferum, is the commercial source for prescription narcotic painkillers such as morphine and codeine. The seeds can be had online and in retail stores. The plants can often be grown if these seeds are not roasted or otherwise sterilized.
I had originally suspected that the CU-Boulder student had not used poppy seed tea but rather some other decoction of the plant itself. I had always contended that the seeds did not…
terrasig | March 21, 2009After writing this post, I came across Alex's obituary and guestbook on Legacy.com. By all accounts, Alex was a great kid - loved and admired by many - an accomplished hockey player and musician with a love for the mountains. This could have been you or I, or worse, one of our own children.
Breaking my heart this morning is news from Boulder that last month's death of 20-year-old CU student, Alexander McGuiggan, was from consumption of "opium tea."
Police department spokeswoman Sarah Huntley said investigators believe McGuiggan and others had acquired poppy plants -- which are available…
terrasig | March 15, 2009I am truly humbled by reader response to my Thursday post on the 12th anniversary of my father's death. What began as a simple journaling exercise interspersed with some great photos provided by my sister has become one of my most highly-read and most-commented posts.
I don't want to comment too much lest I take away what this post has meant to me and others. But for background, this is something that I had intended to write for the 10th anniversary of Dad's passing. However, I had only been with ScienceBlogs for a few months and wasn't yet in a position to write so frankly and personally…
terrasig | March 12, 2009Today marks 12 years since you died.
Well, it might have been today, possibly yesterday, I hope not too many days ago.
You see, you died alone in your apartment you rented from your sister downstairs. Yet no one checked on you as your mail accumulated Monday and Tuesday. One of your drinking buddies from the Disabled American Veterans post told me proudly at your funeral that he probably had with you your last beer that Saturday night. So, maybe it was the 8th or 9th?
When I think back, though, I believe you died some eight years earlier, just after your 50th birthday party. For your…
terrasig | March 9, 2009
I'm very proud today to see one of my formative professors, Dr Fulton Crews, quoted extensively in a USAToday article on a new, web-based alcohol awareness initiative, "Rethinking Drinking," from NIH's National Institute for Alcohol Abuse and Alcoholism (NIAAA) Division of Treatment and Recovery Research.
While many associate heavy drinking with liver problems, it can also increase the risk for heart disease, sleep disorders, depression, stroke and stomach bleeding. Consumed during pregnancy, it can cause fetal brain damage, says Fulton Crews, director of the Bowles Center for Alcohol…
terrasig | February 23, 2009Welcome 4 March readers of The Daily Grail - please be sure to also click on the original post about the DMT article by my colleague, Laura Mariani.
Thanks to Dave Munger & Co's ResearchBlogging.org, I just found a fabulous neuroscience grad student blogger from Emory University: Laura E Mariani at Neurotypical?
Doctor-to-be Mariani blogged last Monday about a paper in Science where the endogenous ligand of the orphan sigma-1 receptor was identified as the hallucinogen, N,N'-dimethyltryptamine, or DMT. The work originated with the group of Arnold Ruoho and colleagues at the University…
terrasig | February 14, 2009Yes, this is what happens when two scientists stay home on Valentine's evening. PharmGirl just fed me the story from CNN about the San Jose high school kid who died yesterday after being taken unconscious from his house on Thursday.
The national and local stories indicate that "two pans containing hydrogen sulfide were found on a table in the teenager's bedroom."
Hydrogen sulfide, H2S, is a gas, one that smells of rotting eggs.
The only way it could be in liquid form is if it were bubbled through water or some other solvent.
But why would a kid have pans of liquid with H2S?
My gut made me…
terrasig | October 12, 2008When dialing up SiteMeter this morning over the first cup of coffee, I noted an unusually large number of hits coming from Fark.com to my post on a NEJM article detailing lead poisoning cases among marijuana users in Germany.
In that article, lead shavings were used to boost dime bags that were "a little light." The combustion of the particles lead to lead poisoning in users and is one of the few scenarios where use of a chelating agent ((2,3-dimercaptosuccinic acid; DMSA; succimer; Chemet®) was both indicated and effective.
Turns out that the Fark.com hits today are coming from a forum…
terrasig | August 28, 2008To coincide with the Nature Science Blogging 2008 conference this weekend in London, we present this guest post from Coracle, the away-from-the-bench scientist who writes the Science and Progress blog. I've long been a fan of Science and Progress and Coracle shares my love of natural products pharmacology and skeptical eye for alternative medicine.
If you're in London and see Coracle at the conference, please buy him a pint and send me the bill.
"Last Friday, April 16th, 1943, I was forced to interrupt my work in the laboratory in the middle of the afternoon, being affected with a…
terrasig | August 13, 2008Most people know of methadone as a long-term substitution therapy for people addicted to heroin, morphine, or other similar drugs called opiates or opioids. A good, free full-text description of methadone maintenance therapy (MMT) can be found in the 15 June 2001 issue of American Family Physician.
Now, in the 1 August 2008 issue of Cancer Research, Claudia Friesen and colleagues at the University of Ulm report that methadone can kill leukemia cells in culture and reverse acquired resistance to other drugs like doxorubicin (Adriamycin). Press reports to this effect appeared at the beginning…
terrasig | June 25, 2008When I first heard that 24-year-old British singer-songwriter Amy Winehouse was hospitalized with early stage emphysema I said "what?" DrugMonkey, a drug-abuse research colleague, has a terrific post up now on the link between Winehouse's crack cocaine use, possible genetic predisposition, and the emergence of early-onset emphysema.
While sad to see a very young person so afflicted, I tend to be fascinated scientifically by these odd medical cases involving natural products - often drugs of abuse.
I'm also particularly impressed by Amy Winehouse's tremendous vocal talents and songwriting…
terrasig | June 23, 2008John Lynch let us know last evening about Carlin's passing on Sunday. I think you'll find many people sharing their favorite George Carlin moments today. I found him to be remarkably observant on how language is used to deal with social and political issues ("shell shock" became "battle fatigue" which then became "post-traumatic stress disorder').
The man also clearly had some interests in pharmacology, particularly natural products - from the AP report:
Despite his reputation as unapologetically irreverent, Carlin was a television staple through the decades, serving as host of the "…
terrasig | April 12, 2008". . .you got marijuana in my lead."
Two great tastes that do not go great together (with apologies).
[Welcome Fark.com readers on 12 Oct 2008 - I comment on the recent story here and you can read our other posts on drugs of abuse here. Thanks for stopping by - APB]
A concise but fascinating medical detective story appears in the letters of this week's (10 Apr 2008) issue of the New England Journal of Medicine (free full text at the time of this posting.).
An astute group of physicians at Leipzig Hospital in Germany noted a local surge of young people presenting with classic symptoms of…