cancer
oracknows | October 8, 2015Yesterday, I wrote about the winner of the Nobel Prize in Physiology or Medicine, Youyou Tu, who, after screening 2,000 herbal treatments from traditional Chinese medicine (TCM) for anti-malaria activity, finally discovered Artemisinin. She isolated it from the plant in which it is found, using modern chemistry to isolate it, purify it, and later chemically modify it to make it more active against malaria. Tu deserved the Nobel Prize for her years of screening. As I pointed out, contrary to how the awarding of the Nobel Prize to Tu is being spun, it is not a validation of TCM, but rather of…
oracknows | October 2, 2015I've written many times about how the relationship between the early detection of cancer and decreased mortality from cancer is not nearly as straightforward as the average person—even the average doctor—thinks, the first time being in the very first year of this blog's existence. Since then, the complexities and overpromising of various screening modalities designed to detect disease at an early, asymptomatic phase have become a relatively frequent topic on this blog. Even more than ten years ago, I noted that screening MRI for breast cancer and whole body CT scans intended to detect other…
oracknows | September 28, 2015A week ago, I noted that one of the stranger and less credible conspiracy theories promulgated by quacks and their believers was still going strong nearly three months after the first death that triggered it, the death of autism quack Jeff Bradstreet, apparently by suicide. Basically, three months ago, Dr. Bradstreet, who has long been a fixture in the "autism biomed" movement and a frequent speaker at autism quackfests like Autism One, was found dead in a river from a gunshot wound to the chest, an apparent suicide. A recent story about the investigation into Dr. Bradstreet's death included…
cmonforton | September 25, 2015The American Chemistry Council (ACC) has teamed up with the Environmental Defense Fund (EDF) to push a bill in Congress to amend the Toxic Substances Control Act of 1976 (TSCA). We’ve written previously (e.g., here, here, here) about this flawed legislation (S.697). Regrettably, it has 55 Republicans and Democrats supporting it and the full Senate will likely be voting on the bill in the coming weeks.
Although EDF and ACC assert broad support for the legislation, I wish the Senators would pay attention to the 450 health, environmental and labor groups that oppose S.697. Their coalition is…
oracknows | September 25, 2015Yesterday, I wrote about how pediatric neurosurgeon turned presidential candidate Ben Carson is an excellent example demonstrating how the vast majority of physicians and surgeons, even highly accomplished ones admired as being at the top of their professions, are not scientists and how many of them are disturbingly prone to buying into pseudoscience. In Dr. Carson's case, that tendency to believe in pseudoscience derives from his fundamentalist religion that led him to reject evolution and accept arguments against evolution every bit as ignorant as the ones Kent Hovind or Ken Ham serves up…
oracknows | September 17, 2015It just occurred to me that Breast Cancer Awareness Month is fast approaching, not the least of which because I did a Komen event last night as one of the breast cancer experts. I sometimes wonder if I suffer from a bit of the imposter syndrome, because sixteen years on I still sometimes can't believe that I'm considered some sort of "expert" in breast cancer, much less anything else. It's not that different than when, as a freshly minted faculty member, I was sent out to our cancer center's affiliates to attend their tumor boards as the "expert" from the mother ship.
In any case, in my…
dr. dolittle | September 14, 2015Dr. Mark Mamula at Yale University has been working on developing a vaccine for cancer. Here is an interview featuring Dr. Mamula discussing how dogs are helping researchers test a vaccine that so far, has shown promise in fighting cancer growth.
Video Source:
NBC www.King5.com
oracknows | September 14, 2015[Note: My flight home from London was delayed until quite late; so unfortunately another "rerun" is in order. This one's from three years ago, and I actually consider it one of my "classics." It was also originally published at my not-so-super-secret other blog and represents the first time I tried to put together my concept of a "central dogma" of alternative medicine into a semi-coherent form. Ultimately, this lead to my talk The Central Dogma of Alternative Medicine, given at Skepticon last year. If you've been reading less than three years, it's new to you. If you haven't, you really…
oracknows | September 9, 2015Orac's vacation continues apace.
Well, not quite. The main reason I'm in London right now is because I was invited to give an actual scientific (as opposed to skeptical) talk at a conference about—of all things—ion channels in cancer. That's where I am right now, at the Sir Alexander Fleming Building at Imperial College London, and that's where I'll be all day today and much of tomorrow. Having been invited, I decided to make a vacation of it. Basically, it's a big science sandwich, with two science days in the middle of two slices of vacation bread. I would also be lying if I didn't admit to…
oracknows | September 8, 2015I am fortunate to have become a physician in a time of great scientific progress. Back when I was in college and medical school, the thought that we would one day be able to sequence the human genome (and now sequence hundreds of cancer genomes), to measure the expression of every gene in the genome simultaneously on a single "gene chip," and to assess the relative abundance of every RNA transcript, coding and noncoding (such as microRNAs) simultaneously through next generation sequencing (NGS) techniques was considered, if not science fiction, so far off in the future as to be unlikely to…
oracknows | September 3, 2015You'd think that after all these years combatting quackery and blogging about science in medicine (and, unfortunately, pseudoscience in medicine) it would take a lot to shock me. You'd be right. On the other hand, Even now, 15 years after I discovered quackery in a big way on Usenet and ten years after the inception of this blog, I still have enough hope in humanity that even when I come across men like Jerry Sargeant, a.k.a. The Facilitator I am still capable of utter wonder that someone would advertise something as reprehensible and/or deluded as this. I half wondered if it were performance…
oracknows | August 31, 2015I didn't think I'd be writing about acupuncture again so soon after deconstructing another "bait and switch" acupuncture study less than a week ago. True, the quackery that is acupuncture and the seemingly unending varieties of low quality studies published to make it seem as though there is anything more than nonspecific placebo effects invoked by sticking needles into the skin against an even more unending variety of diseases, conditions, and complaints. Basically, according to its adherents, acupuncture can treat almost anything. Particularly galling to me as a cancer surgeon is the…
oracknows | August 27, 2015After a busy day yesterday and falling asleep early on the couch, I only have time for a quick take today. So file this under "only in America":
A 23-year-old Metro Detroit man robbed a South Lyon credit union earlier this month for his daughter, he told investigators according to South Lyon Police Lt. Chris Sovik.
Brian Randolph, who is currently jailed on a $500,000 bond and facing up to life in prison for robbery of a banking institution, told detectives he recently lost insurance coverage necessary to pay for cancer treatment his daughter required, Sovic said.
Randolph said his daughter…
cmonforton | August 22, 2015On August 6, two unrelated events got my attention. The first was OSHA’s announcement of a long overdue regulatory proposal. The agency released a proposed rule to protect the health of about 35,000 US workers who are exposed to beryllium. The lightweight, super-strong metal can cause a disabling respiratory disorder called chronic beryllium disease, as well as lung cancer. There is no safe level of exposure to it. The second event was the Fox News debate featuring ten Republicans vying to be the party’s 2016 Presidential candidate.
With the OSHA proposed rule fresh on my mind, I watched the…
oracknows | August 21, 2015I've written more times than I can remember about the phenomenon of overdiagnosis and the phenomenon that is linked at the hip with it, overtreatment. Overdiagnosis is a problem that arises when large populations of asymptomatic, apparently healthy people are screened for a disease or a condition, the idea being that catching the disease at an earlier stage in its progression will allow for more successful treatment. Two prominent examples include—of course—screening for breast cancer with mammography and screening for prostate cancer with prostate-specific antigen (PSA) testing, and I've…
oracknows | August 17, 2015A recurring topic on this blog involves my discussion of stories about children with cancer whose parents refuse chemotherapy, thus endangering the children's lives. These stories usually take this general form: The child is diagnosed with a deadly, but treatable cancer that has a high probability of cure with proper chemotherapy. The child receives the first round of chemotherapy. The parents can't deal with the side effects. If they are woo-prone, they make the decision to use "natural healing" or some form of alternative medicine. Sometimes it's in response to the child's request.…
oracknows | August 14, 2015File this one under the category: You can't make stuff like this up. (At least, I can't.)
Let's say you're a die hard all-conspiracy conspiracy theorist and alternative medicine believer (a not uncommon combination). You love Alex Jones and Mike Adams and agree with their rants that there is a New World Order trying to suppress your rights. You strongly believe that vaccines not only cause autism, sudden infant death syndrome, a shaken baby-like syndrome, autoimmune diseases, sudden ovarian failure, and even outright death but are a depopulation plot hatched by Bill Gates and the Illuminati…
cmonforton | August 6, 2015OSHA announced today that it is proposing a health standard to protect workers who are exposed to beryllium. Exposure to the lightweight but super strong metal causes a debilitating illness called chronic beryllium disease (CBD) and lung cancer.
The proposed rule is coming about, in part, because of an effort by those who will be most affected by an OSHA beryllium regulation: the nation’s primary beryllium manufacturer, Materion, and the United Steelworkers (USW). They engaged in two years of negotiations to agree on key provisions of a regulation. In February 2012, they submitted their…
oracknows | August 2, 2015Homeopathy is The One Quackery To Rule Them All.
There, I've started off this post the way I start off most posts about homeopathy, with a statement of just how enormous a pile of pseudoscientific (or rather prescientific) quackery that it is. You'd think that in 2015 no one would believe that diluting a substance (with vigorous shaking between each serial dilution step, of course, in order to "potentize" it) makes its effects stronger or that water has some sort of mystical "memory" that remembers the therapeutic substance but forgets all the other impurities, chemicals, and urine with which…
oracknows | July 28, 2015I hate stories like this, but what I hate even more is the way stories like this are all too commonly reported. Readers have been sending me links to stories about a woman named Alex Wynn that have been published over the last few days, in particular this story about her in the Daily Mail (better known as the Daily Fail when it comes to medical stories). As is the Fail's wont, the headline blares Newlywed shuns chemotherapy for CARROTS as she vows to beat cancer with alternative therapies while trying for a baby - even though doctors warn there's 'no evidence' they work, with a picture of an…