I've written before about the the failure of basic neuroscience research to advance neuropharmacology (at least, it's been a failure so far), but it's nice to see Eric Kandel, my old mentor (and one of my scientific heroes), make the same argument. Kandel began his scientific career as a Freudian psychiatrist - he was soon turned off by the blatant the lack of empiricism - so his recent interest in the biological benefits of talk therapy, and ways of rigorously measuring those benefits, provides an interesting snapshot on the state of neuroscience.
On the one hand, it's sobering that talk therapy remains the most effective treatment for a wide variety of illness, from chronic back pain to depression. Alas, this says more about the failure of pharmacology than it does about the therapeutic value of talk therapy. On the other hand, science is finally beginning to understand the anatomical mechanisms that allow talk therapy to work. We can see how mere words and conversation profoundly influence the activity of the brain. Here's Kandel, writing for the Dana Foundation:
The other thing that has impressed me is that in the last 20 years we've had no advances in pharmacotherapy. We started off with interesting antipsychotic agents, interesting antidepressants, but they really have progressed very modestly. Selective serotonin [re]-uptake inhibitors--each company's copying from the other using exactly the same assays to develop it. Twenty years, and there's general agreement that there is no difference between most of the selective serotonin [re]-uptake inhibitors and no improvement either. A drug sells not because it's any better than any other but because there are major names associated with it.
In schizophrenia, the issue is even worse, because for 45 years there probably hasn't been a better drug. There are drugs that have better side effects, but there have not been major developments in drugs.
The one thing that has become better is the legitimacy of psychotherapy. There are several behavioral therapies out there--interpersonal therapy, cognitive behavioral therapy--that have been shown in rigorous control studies, in depression, for example, to be at least as good as selective serotonin [re]-uptake inhibitors for mild and moderate depression and to be synergistic with drugs in severe depression.
Moreover, we've beginning to identify--particularly in depression--certain areas of the brain that function abnormally. For example, [Emory University psychiatry professor] Helen Mayberg showed that [Brodmann] area 25--the subgenual cingulate cortex--is hyperactive in depression. This area connects to the amygdala; the amygdala also is hyperactive in depression. When patients respond to psychotherapy, those abnormalities reverse. So for the first time we not only have a psychotherapy that works but we have an independent, biological measure, an assay, and we can see to what degree this works.
Thanks Ted!
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Mother-in-law = A woman who destroys her son-in-law's peace of mind by giving him a piece of hers.
Any fool can criticize, condemn, and complain - and most fools do.
It's not that I'm afraid to die, I just don't want to be there when it happens.
Everybody's worried about stopping terrorism. Well, there's a really easy way: stop participating in it.
When I told the people of Northern Ireland that I was an atheist, a woman in the audience stood up and said, 'Yes, but is it the God of the Catholics or the God of the Protestants in whom you don't believe?
In Germany they first came for the Communists, and I didn't speak up because I wasn't a Communist. Then they came for the Jews, and I didn't speak up because I wasn't a Jew. Then they came for the trade unionists, and I didn't speak up because I wasn't a trade unionist. Then they came for the Catholics, and I didn't speak up because I was a Protestant. Then they came for me - and by that time no one was left to speak up.
They say such nice things about people at their funerals that it makes me sad that I'm going to miss mine by just a few days.
What a cruel thing is war: to separate and destroy families and friends, and mar the purest joys and happiness God has granted us in this world; to fill our hearts with hatred instead of love for our neighbors, and to devastate the fair face of this beautiful world.
There is a charm about the forbidden that makes it unspeakably diserable.
Programming is one of the most difficult branches of applied mathematics; the poorer mathematicians had better remain pure mathematicians.
From the moment I picked your book up until I laid it down I was convulsed with laughter. Some day I intend reading it.
Humor is just another defense against the universe.
Humor is just another defense against the universe.
I know that there are people in this world who do not love their fellow human beings, and I hate people like that.
The secret of a good sermon is to have a good beginning and a good ending, then having the two as close together as possible.
I've had a wonderful time, but this wasn't it.
A terrorist is someone who has a bomb, but doesn't have an air force.
It is dangerous to be right when the government is wrong.
Science is like sex: sometimes something useful comes out, but that is not the reason we are doing it
I criticize by creation - not by finding fault.
Throughout American history, the government has said we're in an unprecedented crisis and that we must live without civil liberties until the crisis is over. It's a hoax.
Why don't they make the whole plane out of that black box stuff.
Programming is one of the most difficult branches of applied mathematics; the poorer mathematicians had better remain pure mathematicians.
Any man who is under 30, and is not a liberal, has not heart; and any man who is over 30, and is not a conservative, has no brains.
In the End, we will remember not the words of our enemies, but the silence of our friends.
I have come to believe that the whole world is an enigma, a harmless enigma that is made terrible by our own mad attempt to interpret it as though it had an underlying truth.
There is only one nature - the division into science and engineering is a human imposition, not a natural one. Indeed, the division is a human failure; it reflects our limited capacity to comprehend the whole.
It's not that I'm afraid to die, I just don't want to be there when it happens.
It's not that I'm afraid to die, I just don't want to be there when it happens.
Ever notice that anyone going slower than you is an idiot, but anyone going faster is a maniac?
A terrorist is someone who has a bomb, but doesn't have an air force.
A terrorist is someone who has a bomb, but doesn't have an air force.
Ever notice that anyone going slower than you is an idiot, but anyone going faster is a maniac?
Be tolerant of the human race. Your whole family belongs to it -- and some of your spouse's family too.
Be tolerant of the human race. Your whole family belongs to it -- and some of your spouse's family too.
Physics is not a religion. If it were, we'd have a much easier time raising money.
I have often regretted my speech, never my silence.
In any contest between power and patience, bet on patience.
It's not the size of the dog in the fight, it's the size of the fight in the dog.
It's not the size of the dog in the fight, it's the size of the fight in the dog.
Sterling's Corollary to Clarke's Law: Any sufficiently advanced garbage is indistinguishable from magic.
Sterling's Corollary to Clarke's Law: Any sufficiently advanced garbage is indistinguishable from magic.
The first half of our life is ruined by our parents and the second half by our children.
The first half of our life is ruined by our parents and the second half by our children.
It's not the size of the dog in the fight, it's the size of the fight in the dog.
It's not the size of the dog in the fight, it's the size of the fight in the dog.
It's not the size of the dog in the fight, it's the size of the fight in the dog.
I was raised in the West. The west of Texas. It's pretty close to California. In more ways than Washington, D.C., is close to California.
I was raised in the West. The west of Texas. It's pretty close to California. In more ways than Washington, D.C., is close to California.
University politics are vicious precisely because the stakes are so small.
University politics are vicious precisely because the stakes are so small.
University politics are vicious precisely because the stakes are so small.
If electricity comes from electrons, does that mean that morality comes from morons?
Whenever I climb I am followed by a dog called 'Ego'.
Humor is always based on a modicum of truth. Have you ever heard a joke about a father-in-law?
In America, anybody can be president. That's one of the risks you take.
I have four children which is not bad considering I'm not a Catholic.
To understand a man you should walk a mile in his shoes. If what he says still bothers you that's ok because you'll be a mile away from him and you'll have his shoes.
We need either less corruption or more chance to participate in it.
If Stupidity got us into this mess, then why can't it get us out?
A lady came up to me on the street, pointed at my suede jacket and said, 'Don't you know a cow was murdered for that jacket?' I said 'I didn't know there were any witnesses. Now I'll have to kill you too'.
Those are my principles. If you don't like them I have others.
In Germany they first came for the Communists, and I didn't speak up because I wasn't a Communist. Then they came for the Jews, and I didn't speak up because I wasn't a Jew. Then they came for the trade unionists, and I didn't speak up because I wasn't a trade unionist. Then they came for the Catholics, and I didn't speak up because I was a Protestant. Then they came for me - and by that time no one was left to speak up.
The whole problem with the world is that fools and fanatics are always so certain of themselves, but wiser people so full of doubts.
Every journalist has a novel in him, which is an excellent place for it.
hen they came for the trade unionists, and I didn't speak up because I wasn't a trade unionist. Then they came for the Catholics, and I didn't speak up because I was a Protestant. Then they came for me - and by that time no one was left to speak up.
BASIC: as potential programmers they are mentally mutilated beyond hope of regeneration.
He had decided to live forever or die in the attempt.
A good sermon should be like a woman's skirt: short enough to arouse interest but long enough to cover the essentials.
I'm always amazed to hear of air crash victims so badly mutilated that they have to be identified by their dental records. What I can't understand is, if they don't know who you are, how do they know who your dentist is?
Not only is there no God, but you try getting a plumber at weekends.
Three o'clock is always too late or too early for anything you want to do.
Against stupidity the (very) gods themselves contend in vain
I am ready to meet my Maker. Whether my Maker is prepared for the great ordeal of meeting me is another matter.
A state of war only serves as an excuse for domestic tyranny.
If you're sick and tired of the politics of cynicism and polls and principles, come and join this campaign.
Instead, I was a painter, and became Picasso.
Not only is there no God, but you try getting a plumber at weekends.
Ever notice that anyone going slower than you is an idiot, but anyone going faster is a maniac?
Researchers have discovered that chocolate produces some of the same reactions in the brain as marijuana. The researchers also discovered other similarities between the two but can't remember what they are.
If the United Nations once admits that international disputes can be settled by using force, then we will have destroyed the foundation of the organization and our best hope of establishing a world order.
As the post said, 'Only God can make a tree,' probably because it's so hard to figure out how to get the bark on.
Research is what I'm doing when I don't know what I'm doing.
The President has kept all of the promises he intended to keep.
The President has kept all of the promises he intended to keep.
Emulate your heros, but don't carry it too far. Especially if they are dead.
I have had a perfectly wonderful evening, but this wasn't it.
Whatever is begun in anger ends in shame.
And God said, 'Let there be light' and there was light, but the Electricity Board said He would have to wait until Thursday to be connected.
Against stupidity the (very) gods themselves contend in vain
I don't know why we are here, but I'm pretty sure that it is not in order to enjoy ourselves.
It is practically imposible to teach good programming to students that have had a prior exposure to BASIC: as potential programmers they are mentally mutilated beyond hope of regeneration.
There is no reason anyone would want a computer in their home.
There are some experiences in life which should not be demanded twice from any man, and one of them is listening to the Brahms Requiem.
There are people in the world so hungry, that God cannot appear to them except in the form of bread.
There are people in the world so hungry, that God cannot appear to them except in the form of bread.
I hear Glenn Hoddle has found God. That must have been one hell of a pass.
Absence of evidence is not evidence of absence.
The world is a tragedy to those who feel, but a comedy to those who think.
The world is a tragedy to those who feel, but a comedy to those who think.
There are people in the world so hungry, that God cannot appear to them except in the form of bread.
There are people in the world so hungry, that God cannot appear to them except in the form of bread.
It was God who made me so beautiful. If I weren't, then I'd be a teacher.
I once heard two ladies going on and on about the pains of childbirth and how men don't seem to know what real pain is. I asked if either of them ever got themselves caught in a zipper.
I once heard two ladies going on and on about the pains of childbirth and how men don't seem to know what real pain is. I asked if either of them ever got themselves caught in a zipper.
You have a cough? Go home tonight, eat a whole box of Ex-Lax -- tomorrow you'll be afraid to cough.
I'm all in favor of keeping dangerous weapons out of the hands of fools. Let's start with typewriters.
A fast word about oral contraception. I asked a girl to go to bed with me, she said 'no'.
Once you eliminate the impossible, whatever remains, no matter how improbable, must be the truth.
Chaos Theory is a new theory invented by scientists panicked by the thought that the public were beginning to understand the old ones.
Genius may have its limitations, but stupidity is not thus handicapped.
The world is a tragedy to those who feel, but a comedy to those who think.
Democracy is where you can say what you think even if you don't think.
I've never seen anyone change his mind because of the power of a superior argument or the acquisition of new facts. But I've seen plenty of people change behavior to avoid being mocked.
If thereÂs one thing I know itÂs God does love a good joke.
What is morally wrong can never be advantageous, even when it enables you to make some gain that you believe to be to your advantage.
Learning is what most adults will do for a living in the 21st century.
Nothing is wrong with California that a rise in the ocean level wouldn't cure.
I was raised in the West. The west of Texas. It's pretty close to California. In more ways than Washington, D.C., is close to California.
I'm not under the alkafluence of inkahol that some thinkle peep I am. It's just the drunker I sit here the longer I get.
Defining and analyzing humor is a pastime of humorless people.
Whether you think that you can, or that you can't, you are usually right.
Life would be so much easier if we could just see the source code.
Science is what people understand well enough to explain to a computer. All else is art.
We all agree that your theory is crazy, but is it crazy enough?
When did I realize I was God? Well, I was praying and I suddenly realized I was talking to myself.
I was raised in the West. The west of Texas. It's pretty close to California. In more ways than Washington, D.C., is close to California.
The chain reaction of evil -- wars producing more wars -- must be broken, or we shall be plunged into the dark abyss of annihilation.
Chaos Theory is a new theory invented by scientists panicked by the thought that the public were beginning to understand the old ones.
A coward is a hero with a wife, kids, and a mortgage.
I wouldn't mind dying - it's the business of having to stay dead that scares the shit out of me.
If you're sick and tired of the politics of cynicism and polls and principles, come and join this campaign.
There's many a bestseller that could have been prevented by a good teacher.
The only rules comedy can tolerate are those of taste, and the only limitations those of libel.
If the United Nations once admits that international disputes can be settled by using force, then we will have destroyed the foundation of the organization and our best hope of establishing a world order.
Success usually comes to those who are too busy to be looking for it
> > > Goodbye to all! Thanks for years of great fun and good > > > business! > > Suicide or MS C++? > Is there a difference? Suicide hurts only once...
It's wonderful to be here in the great state of Chicago.
The optimist proclaims that we live in the best of all possible worlds, and the pessimist fears this is true.
Success usually comes to those who are too busy to be looking for it
If people can judge me on the company I keep, they would judge me with keeping really good company with Laura.
It's clearly a budget. It's got a lot of numbers in it.
The best way to predict the future is to invent it.
Heaven is an American salary, a Chinese cook, an English house, and a Japanese wife. Hell is defined as having a Chinese salary, an English cook, a Japanese house, and an American wife.
The shepherd always tries to persuade the sheep that their interests and his own are the same.
It's the liberal bias. The press is liberally biased to the right.
Chaos Theory is a new theory invented by scientists panicked by the thought that the public were beginning to understand the old ones.
Descended from the apes? Let us hope that it is not true. But if it is, let us pray that it may not become generally known.
I must confess, I was born at a very early age.
If electricity comes from electrons, does that mean that morality comes from morons?
TV is called a medium because it is neither rare nor well done.
We should leave our minds open, but not so open that our brains fall out.
To err is human -- and to blame it on a computer is even more so.
Mother-in-law = A woman who destroys her son-in-law's peace of mind by giving him a piece of hers.
You got to be careful if you don't know where you're going, because you might not get there.
If the automobile had followed the same development cycle as the computer, a Rolls-Royce would today cost $100, get a million miles per gallon, and explode once a year, killing everyone inside.
They show you how detergents take out bloodstains. I think if you've got a T-shirt with bloodstains all over it, maybe your laundry isn't your biggest problem.
The Bible was a consolation to a fellow alone in the old cell. The lovely thin paper with a bit of matress stuffing in it, if you could get a match, was as good a smoke as I ever tasted.
Once you eliminate the impossible, whatever remains, no matter how improbable, must be the truth.
Science is what people understand well enough to explain to a computer. All else is art.
Manuscript: something submitted in haste and returned at leisure.
The music business is a cruel and shallow money trench, a long plastic hallway where thieves and pimps run free, and good men die like dogs. There's also a negative side
So I rang up a local building firm, I said 'I want a skip outside my house.' He said 'I'm not stopping you.'
A blind bloke walks into a shop with a guide dog. He picks the Dog up and starts swinging it around his head. Alarmed, a shop assistant calls out: 'Can I help, sir?' 'No thanks,' says the blind bloke. 'Just looking.'
Instead, I was a painter, and became Picasso.
Getting an education was a bit like a communicable sexual disease. It made you unsuitable for a lot of jobs and then you had the urge to pass it on.
Good people do not need laws to tell them to act responsibly, while bad people will find a way around the laws.
I was raised in the West. The west of Texas. It's pretty close to California. In more ways than Washington, D.C., is close to California.
Show me a sane man and I will cure him for you.
The President has kept all of the promises he intended to keep.
Glory is fleeting, but obscurity is forever.
Clothes make the man. Naked people have little or no influence on society.
Talk sense to a fool and he calls you foolish.
He has all the virtues I dislike and none of the vices I admire.
Object-oriented programming is an exceptionally bad idea which could only have originated in California.
Why was I with her? She reminds me of you. In fact, she reminds me more of you than you do!
A physicist is an atom's way of knowing about atoms.
Happiness is good health and a bad memory.
There is no reason anyone would want a computer in their home.
If people can judge me on the company I keep, they would judge me with keeping really good company with Laura.
You got to be careful if you don't know where you're going, because you might not get there.
The use of COBOL cripples the mind; its teaching should, therefore, be regarded as a criminal offense.
Dying is a very dull, dreary affair. And my advice to you is to have nothing whatever to do with it.
Devlin's First Law - Buyer beware: in the hands of a charlatan, mathematics can be used to make a vacuous argument look impressive. Devlin's Second Law - So can PowerPoint.
Only one man ever understood me, and he didn't understand me.
I failed to make the chess team because of my height.
Early to rise and early to bed. Makes a male healthy, wealthy and dead.
The bureaucracy is expanding to meet the needs of an expanding bureaucracy.
Invading Iraq after 9/11 was like invading Mexico after Pearl Harbor.
The secret to creativity is knowing how to hide your sources.
The only difference between me and a madman is that I'm not mad.
Ever since I started working out I've been able to sleep like a baby, I think most people can't sleep because they don't use up enough calories in their day.
Regard, do you think, if you make as you wrote in your comunity, then something will happen? Or, you can not even try? Something like that I've seen this blog
Regard, do you think, if you make as you wrote in your comunity, then something will happen? Or, you can not even try? Something like that I've seen this blog
In the whole world's time, at some dated, our inner fire goes out. It is then blow up into passion beside an face with another hominoid being. We should all be glad quest of those people who rekindle the inner spirit
I don't like the durable of all those lists he's making - it's like fetching too divers notes at seminary; you sense you've achieved something when you haven't.
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In everyone's life, at some dated, our inner foment goes out. It is then burst into flame at near an be faced with with another hominoid being. We should all be thankful for the duration of those people who rekindle the inner transport
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I can't believe its not butter!
Compadezco, pero de nada no es posible hacer.
In connected thing, Nike's new slogan for Tiger Woods is Just do me.
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Several teachers emphasize the grip very first when working using a new pupil, even if the pupil is an intermediate or advanced participant.
You also find out from expertise that students can, actually, convert know-how into talent.
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Pondering great is in fact the American Way and that what produced our nation affluent.
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I learned that courage was not the absence of fear, but the triumph over it. The brave man is not he who does not feel afraid, but he who conquers that fear.
The story is like "What will happen if the villain defeated the hero?".
I guess what I'm trying to say is, I don't think you can measure life in terms of years. I think longevity doesn't necessarily have anything to do with happiness. I mean happiness comes from facing challenges and going out on a limb and taking risks. If you're not willing to take a risk for something you really care about, you might as well be dead.
Emotionally and mentally distancing oneself out of your ex lover is an crucial step in finding out the best way to get your ex-girlfriend guy again. While this might seem counterintuitive, it really is in fact important to take oneself out in the predicament mentally, removing the stress related with the break up. Once you are feeling more calmed and relaxed, and he is feeling the same, this can be when real resolution can eventually develop into a part of the dialogue in between the two of you.
I think if you've got a T-shirt with bloodstains all over it, maybe your laundry isn't your biggest problem.
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No one who cannot rejoice in the discovery of his own mistakes deserves to be called a scholar.
A little government and a little luck are necessary in life, but only a fool trusts either of them.
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I tried all day to think of some witty comment to write on your blog but all I got is âWar doesnât determine whoâs right. War determines whoâs left.â
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The bond of love between a mother and child is so powerful that it is felt in Heaven.
Foi um momento muito importante para a primeira demonstração da socialização das crianças novas e o exercÃcio de acolhimento pelos alunos que já são da instituição. Adauga Anunturi Gratuite Botosani
Don't think allot off people share the same argument, but i don't think this is all true.
This post will be in my head for a very long time.
Muchas Gracias for the "work" you put into your blog says my aunt
Recede imbecility or you will study this disorder
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Between me and my husband we've owned more MP3 players over the years than I can count, including Sansas, iRivers, iPods (classic & touch), the Ibiza Rhapsody, etc. But, the last few years I've settled down to one line of players. Why? Because I was happy to discover how well-designed and fun to use the underappreciated (and widely mocked) Zunes are.
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Bing! i recommend it!
I am not sure if I agree with you. Anyway will keep looking
hi, discovered your place on Bing, which I never use while looking for something entirely different. So much for my schedule today. Thanks. ;)
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Ilk a man as he loves, let him send to the Cooks,
Sie der abstrakte Mensch
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Where do you come up with this? Just saying you are very imaginative. Do you still feel this way?
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OK, here I go again! Another one that I completely screwed up. Oh, well, nobody is perfect!
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If I agreed with you we'd both be wrong.
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On a different note, I find it sad that Winslet wins an Oscar specifically now, when she is clearly thinner than she has been in the past.
I forgot to ask. You talked about a comment policy. Have you placed this somewhere on the blog or is it just your own moderation guidelines?
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echt gut, daà das brisante Thema wirklich direkt angesprochen wird. Dein Post hat mir richtig gefallen, allerdings teile ich diese Meinung nicht hundertprozentig. Aber ich glaube Post ;-)
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You are posting recent blog entries on twitter as well? If so I would like to know your account, so I can follow you there and be informed.
You are posting recent blog entries on twitter as well? If so I would like to know your account, so I can follow you there and be informed.
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Please how much is the Certification test? and What are eligibility requirements?
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