Children and cancer
terrasig | June 30, 2009
I love it when new readers stumble upon old posts.
Such was the case when I received the following delightful comment from Seattle-based psychologist, Dr Gary Grenell, on my April 2008 post about the passing of Dr Charlotte Tan, a pediatric cancer chemotherapy pioneer:
I was probably in one of her earliest actionmycin-D trial groups for Wilms tumor in 1957. Now at age 55, 52 years later, still going strong!
Most of you scientific youngsters today probably only know of actinomycin D as a laboratory tool for inhibiting RNA synthesis. But here in the following repost, learn about the…
terrasig | November 20, 2008Just a quick reminder of who you're really supporting when you come by and click on this humble blog.
It's no secret that joining Seed Media Group's ScienceBlogs.com can bring the blogger(s) a very small amount of compensation based upon grades of site traffic - depending on your traffic, this could be about as much as paying for your monthly highspeed internet connection at the house. But over the course of a year, this ends up being more money than I donate personally to my public radio station.
Anyway, when I started Terra Sig at the old joint and was invited to join Sb, I was in a…
When medical experimental therapeutics gets co-opted as complementary and alternative medicine (CAM)
terrasig | May 8, 2008Sorry to get to this so late but I wanted to weigh on an excellent post from my cancer blogging colleague, Orac, the other day on the investigation of CAM therapies in cancer. The post covers a lot of ground, as expected from any of Orac's exhaustive missives, but I wanted to focus on the comparison and contracts between NIH's National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Cancer Complementary and Alternative Medicine within the National Cancer Institute (NCI-OCCAM).
I am on record as a strong critic of NCCAM but a supporter of NCI's OCCAM in that the…
terrasig | April 4, 2008Actinomycin D was the first antitumor antibiotic isolated from Streptomyces parvallus cultures by the lab of 1952 Nobel laureate, Dr Selman Waksman, at Rutgers University. However, it took a young Chinese physician and the confidence in her by a future US Surgeon General for this natural product drug to positively impact the lives of children with cancer.
An unusually engaging Boston Globe obituary by Gloria Negri caught my attention this week that announced the death of pediatric oncology pioneer, Charlotte Tan (Hsu), MD, of pneumonia on 1 April in Brookline, MA. Dr Tan's 1959 paper in…
terrasig | September 16, 2007Leukemia Drug Adulteration
Chinese generic versions of the anticancer drugs, methotrexate and cytarabine hydrochloride, have been reported to be contaminated with an undisclosed substance according to several wire reports this morning.
Several children in a Shanghai hospital were reported to suffer leg pain and difficulty walking after being injected with methotrexate. A common drug used in many chemotherapy regimens for leukemia, methotrexate is not normally associated with these side effects.
The Xinhua news agency reported that the drugs had been traced to one manufacturer, Shanghai…
terrasig | December 27, 2006A week after my colleague Orac posts on the conundrum of bringing religion into medicine, Michael Conlon reports on a nurse's book about how religious and cultural influences can compromise medical care:
Any nurse can walk into a bad situation. The one Luanne Linnard-Palmer can't forget came as she readied a little boy for a blood transfusion only to be told by his mother "You know you're damning his soul to hell!"
The child's mother was a Jehovah's Witness, a faith that rejects blood transfusions. Her son had sickle cell anemia and had become extremely weak.
"It blew me away," Linnard-Palmer…
terrasig | December 12, 2006I finally just got around to reading the 1 Dec issue of the Journal of Clinical Oncology and was struck by two, back-to-back articles that address two interesting aspects of alternative medicine in cancer treatment. Mind you, I'm a basic scientist but I find the struggles that oncologists face to be quite interesting in this regard.
First is an article (free full text here) from a feature called, The Art of Oncology: When the Tumor is not the Target. The title alludes to some high-profile legal cases that arose over the summer, but does not discuss specifically the Cherrix case:
Do…
terrasig | August 18, 2006I've stayed out of the Starchild Abraham Cherrix case, where a 16-year-old boy and his parents are trying to refuse known, effective, and life-saving chemotherapy for a curable cancer in lieu of a scientifically unproven alternative regimen that includes coffee enemas.
Orac of Respectful Insolence has been most prolific in commenting on the issues at hand and yesterday, The Cheerful Oncologist, weighed in. I'm happy about this because both fellas are MDs with highly-specialized oncology training in surgical and medical oncology, respectively. Hence, I defer to them on issues of life and…
terrasig | June 10, 2006[A regular reader, SciMom at Doubleloop, thanked me for putting up this post on my old blog this past Wednesday. As I don't believe that any of my new SiBlings here covered the passing of this amazing scientist, I am reprinting it here for our new and more diverse audience.]
Cancer research and the cause of women in science and medicine lost a true leader and shining example last week with the passing of Dr Anita Roberts to gastric cancer. She was only 64.
From her Washington Post obituary:
Dr. Roberts, the 49th most-cited scientist in the world and the third most-cited female scientist,…
sb admin | June 9, 2006No surprise here: a highly-regarded climatologist declares that the Bush administration is "muzzling government scientists" and covering up the facts about global warming.
Warren Washington, a senior scientist at the National Center for Atmospheric Research in Boulder, said that Bush appointees are suppressing information about climate change, restricting journalists' access to federal scientists and rewriting agency news releases to stress global warming uncertainties.
"The news media is not getting the full story, especially from government scientists," Washington told about 160 people…