antidepressant
dr. dolittle | June 7, 2012
Idiopathic autism has been on the rise in recent years and is thought to be caused by a mixture of genetic risk factors as well as some as yet unknown environmental factors. Research suggests a link between antidepressant use by pregnant women and the development of autism. Further, some unmetabolized psychoactive pharmaceuticals (UPPs) have made their way into drinking water from sources at the surface posing a potential environmental risk of exposure. To study the potential link between UPPs and autism, Drs. Michael Thomas and Rebecca Klaper exposed fathead minnows to a mixture of three…
ddobbs | March 5, 2009Philip Dawdy takes a interesting look at a new study of the safety of placebo arms in clinical trials of antidepressants in teens. My own quick scan of the study [which Dawdy makes available as pdf download] suggests it's full of great nuggets.
Its take-home: Placebo treatments produced remission rates of 48%, while the rate for active treatment was 59%. And, quite interestingly, the study concludes:
Patients who responded to placebo generally retained their response. Those who did not respond to placebo subsequently responded to active treatment at the same rates as those initiallyl…
ddobbs | January 20, 2009One theory about antidepressants is that they relieve depression by encouraging neurogenesis -- the creation of new neurons. Neuroskeptic reviews a study that argues against this idea.
the neurogenesis hypothesis has problems of its own. A new paper claims to add to what seems like a growing list of counter-examples: Ageing abolishes the effects of fluoxetine on neurogenesis.
The researchers, Couillard-Despres et. al. from the University of Regensburg in Germany, found that fluoxetine (Prozac) enhances hippocampal neurogenesis in mice - as expected - but found in addition that this only…
ddobbs | February 26, 2008[This is a revised, expanded version of the original heads-up I put up last night.]
A large new meta-analysis of SSRI antidepressant trials concludes that the drugs have essentially no therapeutic effect at all. The study, in PLOS Medicine today, comes on the heels of another study published a few weeks ago (I blogged on it here) showing that SSRIs have little therapeutic effect if you include the (unflattering) clinical trials the industry had previously hidden.
The PLOS study is a meta-analysis of 47 clinical trials that account for almost all full data on clinical trials of SSRIs such as…